The graphene oxide contradictory effects against human pathogen

Valentina Palmieri et al review the hundreds of papers about the action of graphene against bacteria.

Standing out as the new wonder bidimensional material, graphene oxide (GO) has aroused an exceptional interest in biomedical research by holding promise for being the antibacterial of future. First, GO possesses a specific interaction with microorganisms combined with a mild toxicity for human cells. Additionally, its antibacterial action seems to be directed to multiple targets in pathogens, causing both membranes mechanical injury and oxidative stress. Lastly, compared to other carbon materials, GO has easy and low-cost processing and is environmentfriendly.
This remarkable specificity and multi-targeting antibacterial activity come at a time when antibiotic resistance represents the major health challenge. Unfortunately, a comprehensive framework to understand how to effectively utilize this material against microorganisms is still lacking. In the last decade, several groups tried to define the mechanisms of interaction between GO flakes and pathogens but conflicting results have been reported. This review is focused on all the contradictions of GO antimicrobial properties in solution. Flake size, incubation protocol,
time of exposure and species considered are examples of factors influencing results. These parameters will be summarized and analyzed with the aim of defining the causes of contradictions, to allow fast GO clinical application.

Antibacterial action of graphene oxide, web and press release

The image shows the cutting of bacteria by graphene oxide flakes.

nazione2016

Some Web release

http://www.graphene-info.com/graphene-oxide-helps-creating-antibacterial-cloack

http://lucbourne.scienceblog.com/74/treating-biofilms-to-an-antimicrobial-cloak/

http://www.pubfacts.com/detail/27710143/The-future-development-of-bacteria-fighting-medical-devices-the-role-of-graphene-oxide

More press and web release (.pdf download)

Graphene Pagurus Versus Super Bugs

The super bugs are the plague of modern era. Super bugs are antibiotic resistant bacteria that will cause the death of thousands of people in the future. We need novel tools to sterilize surfaces and medical equipment; we also need novel approaches to defeat bacteria.cancerpagurus

Within a collaboration with the University Cattolica, we recently reported in Scientific Reports on a novel “cloak” against super bugs. The cloak is a laser printed surface that includes graphene oxide. The cloak is able to kill the bacteria because the surface mimics the carapace of the Cancer Pagurus (picture above), which is known to repel dangerous organisms, and also uses graphene as a blade that cuts the bacteria (and also wrap and poison them), as in the following picturecutbacteria

The cloak is a novel very effective solution to sterilize surfaces, and our research sheds light on the effect of graphene against bacteria. We report 90% bacteria killing action.

Web release

http://www.graphene-info.com/graphene-oxide-helps-creating-antibacterial-cloack

http://lucbourne.scienceblog.com/74/treating-biofilms-to-an-antimicrobial-cloak/

http://www.pubfacts.com/detail/27710143/The-future-development-of-bacteria-fighting-medical-devices-the-role-of-graphene-oxide

 

ERC-PoC VANGUARD

The ERC Proof of Concept Grant VANGUARD, acronym for Versatile optomechanicanical graphene device for bio-tissue engineering aims at the realization of a novel bio-inspired laser-driven bio-templating approach for antibacterial surfaces and for tissue engineering.

The project lasts 18 months, ends in September 2016 and is funded by 150keuros

Press release on the VANGUARD project

Antibacterial Action of Graphene