The cascade of resonant -symmetric topological structures is shown to emit laser light with a frequency comb spectrum. We consider optically active topological lattices supporting edge modes at regularly spaced frequencies. When the amplified resonances in the PT-broken regime match the edge modes of the topological gratings, we predict the emission of discrete laser lines. A proper design enables the engineering of the spectral features for specific applications. Topological protection makes the system very well suited for a novel generation of compact frequency comb emitters for spectroscopy, metrology, and quantum information.