Highly accurate biosensors for few or single molecule detection play a central role in numerous key fields, such as healthcare and environmental monitoring. In the last decade, laser biosensors have been investigated as proofs of concept, and several technologies have been proposed. We here propose a demonstration of polymeric whispering gallery microlasers as biosensors for detecting small amounts of proteins down to 400 pg. They have the advantage of working in free space without any need for waveguiding for input excitation or output signal detection. The photonic microsensors can be easily patterned on microscope slides and operate in air and solution. We estimate the limit of detection up to 148 nm/RIU for three different protein dispersions. In addition, the sensing ability of passive spherical resonators in the presence of dielectric nanoparticles that mimic proteins is described by massive ab initio numerical simulations.
Category: Coding
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Variational quantum algorithm for Gaussian discrete solitons and their boson sampling
In the context of quantum information, highly nonlinear regimes, such as those supporting solitons, are marginally investigated. We miss general methods for quantum solitons, although they can act as entanglement generators or as self-organized quantum processors. We develop a computational approach that uses a neural network as a variational ansatz for quantum solitons in an array of waveguides. By training the resulting phase-space quantum machine learning model, we find different soliton solutions varying the number of particles and interaction strength. We consider Gaussian states that enable measuring the degree of entanglement and sampling the probability distribution of many-particle events. We also determine the probability of generating particle pairs and unveil that soliton bound states emit correlated pairs. These results may have a role in boson sampling with nonlinear systems and in quantum processors for entangled nonlinear waves
Quantum Machine Learning course on Github
3D+1 Quantum Nonlocal Solitons with Gravitational Interaction
https://arxiv.org/abs/2202.10741
Nonlocal quantum fluids emerge as dark-matter models and tools for quantum simulations and technologies. However, strongly nonlinear regimes, like those involving multi-dimensional self-localized solitary waves (nonlocal solitons), are marginally explored for what concerns quantum features. We study the dynamics of 3D+1 solitons in the second-quantized nonlocal nonlinear Schroedinger equation. We theoretically investigate the quantum diffusion of the soliton center of mass and other parameters, varying the interaction length. 3D+1 simulations of the Ito partial differential equations arising from the positive P-representation of the density matrix validate the theoretical analysis. The numerical results unveil the onset of non-Gaussian statistics of the soliton, which may signal quantum-gravitational effects and be a resource for quantum computing. The non-Gaussianity arises from the interplay of the quantum diffusion of the soliton parameters and the stable invariant propagation. The fluctuations and the non-Gaussianity are universal effects expected for any nonlocality and dimensiona
All-Optical Scalable Spatial Coherent Ising Machine
Networks of optical oscillators simulating coupled Ising spins have been recently proposed as a heuristic platform to solve hard optimization problems. These networks, called coherent Ising machines (CIMs), exploit the fact that the collective nonlinear dynamics of coupled oscillators can drive the system close to the global minimum of the classical Ising Hamiltonian, encoded in the coupling matrix of the network. To date, realizations of large-scale CIMs have been demonstrated using hybrid optical-electronic setups, where optical oscillators simulating different spins are subject to electronic feedback mechanisms emulating their mutual interaction. While the optical evolution ensures an ultrafast computation, the electronic coupling represents a bottleneck that causes the computational time to severely depend on the system size. Here, we propose an all-optical scalable CIM with fully programmable coupling. Our setup consists of an optical parametric amplifier with a spatial light modulator (SLM) within the parametric cavity. The spin variables are encoded in the binary phases of the optical wave front of the signal beam at different spatial points, defined by the pixels of the SLM. We first discuss how different coupling topologies can be achieved by different configurations of the SLM, and then benchmark our setup with a numerical simulation that mimics the dynamics of the proposed machine. In our proposal, both the spin dynamics and the coupling are fully performed in parallel, paving the way towards the realization of size-independent ultrafast optical hardware for large-scale computation purposes.
https://journals.aps.org/prapplied/abstract/10.1103/PhysRevApplied.16.054022