The website for the MARGO project conference is online
Category: Biophysics
Tsunami of light launched against 3D-printed tumor cells
Nature Communications 14, 4662 (2023)
Extreme waves are intense and unexpected wavepackets ubiquitous in complex systems. In optics, these rogue waves are promising as robust and noise-resistant beams for probing and manipulating the underlying material. Localizing large optical power is crucial especially in biomedical systems, where, however, extremely intense beams have not yet been observed. We here discover that tumor-cell spheroids manifest optical rogue waves when illuminated by randomly modulated laser beams. The intensity of light transmitted through bio-printed three-dimensional tumor models follows a signature Weibull statistical distribution, where extreme events correspond to spatially-localized optical modes propagating within the cell network. Experiments varying the input beam power and size indicate that the rogue waves have a nonlinear origin. We show that these nonlinear optical filaments form high-transmission channels with enhanced transmission. They deliver large optical power through the tumor spheroid, and can be exploited to achieve a local temperature increase controlled by the input wave shape. Our findings shed light on optical propagation in biological aggregates and demonstrate how nonlinear extreme event formation allows light concentration in deep tissues, paving the way to using rogue waves in biomedical applications, such as light-activated therapies.
Biosensing with free space whispering gallery mode microlasers
Highly accurate biosensors for few or single molecule detection play a central role in numerous key fields, such as healthcare and environmental monitoring. In the last decade, laser biosensors have been investigated as proofs of concept, and several technologies have been proposed. We here propose a demonstration of polymeric whispering gallery microlasers as biosensors for detecting small amounts of proteins down to 400 pg. They have the advantage of working in free space without any need for waveguiding for input excitation or output signal detection. The photonic microsensors can be easily patterned on microscope slides and operate in air and solution. We estimate the limit of detection up to 148 nm/RIU for three different protein dispersions. In addition, the sensing ability of passive spherical resonators in the presence of dielectric nanoparticles that mimic proteins is described by massive ab initio numerical simulations.
Launching optical tsunamis against tumor cells
We demonstrate the excitation of giant rogue waves of light inside human pancreatic tumor cells; they can be used for deep light transport and local heating for cancer treatment.
Rogue waves are intense and unexpected wavepackets ubiquitous in complex systems. In optics, they are promising as robust and noise-resistant beams for probing and manipulating the underlying material. Localizing large optical power is crucial, especially in biomedical systems, where extremely intense beams have not yet been observed. We here discover that tumor-cell spheroids manifest optical rogue waves when illuminated by randomly modulated laser beams. The intensity of light transmitted through bio-printed three-dimensional tumor models follows a signature Weibull statistical distribution, where extreme events correspond to spatially-localized optical modes propagating within the cell network. Experiments varying the input beam power and size indicate that rogue waves have a nonlinear origin. We show these optical filaments form high-transmission channels with enhanced transmission. They deliver large optical power through the tumor spheroid, which can be exploited to achieve a local temperature increase controlled by the input wave shape. Our findings shed new light on optical propagation in biological aggregates and demonstrate how extreme event formation allows light concentration in deep tissues, paving the way to using rogue waves in biomedical applications such as light-activated therapies
MARGO project startup
(Image above from Unsplash collection by Spentys )
Our new project within the Graphene Flagship ( Flagera Call JTC 2019) officially started !
MARGO stands for MAxillofacial bone Regeneration by 3D-printed laser-activated Graphene Oxide Scaffolds
MARGO is an exciting data-driven interdisciplinary research on our previous results on the Antibacterial coating and stem cell replication by Graphene Oxide, following our ERC PoC Project VANGUARD!
See also