In a recent paper, we demonstrated an optical deep neural network with a real living piece of brain tumor (a 3D “tumour model”). We think this is the first example of a hybrid living/photonic hardware: a sort of artificially intelligent device performing optical functions and detecting tumour morphodynamics (including the effect of chemotherapy)
Deep optical neural network by living tumour brain cells
Abstract: The new era of artificial intelligence demands large-scale ultrafast hardware for machine learning. Optical artificial neural networks process classical and quantum information at the speed of light,
and are compatible with silicon technology, but lack scalability and need expensive manufacturing of many computational layers. New paradigms, as reservoir computing and the extreme learning machine, suggest that disordered and biological materials may realize artificial neural networks with thousands of computational nodes trained only at the input and at the readout. Here we employ biological complex systems, i.e., living three-dimensional tumour brain models, and demonstrate a random neural network (RNN) trained to detect tumour morphodynamics via
image transmission. The RNN, with the tumour spheroid 19 as a three-dimensional deep computational reservoir, performs programmed optical functions and detects cancer morphodynamics from laser-induced hyperthermia inaccessible by optical imaging. Moreover, the RNN quantifies the effect of chemotherapy inhibiting tumour growth. We realize a non-invasive smart probe for cytotoxicity assay, which is at least one order of magnitude more sensitive with respect to conventional imaging. Our random and hybrid photonic/living system is a novel artificial machine for computing and for the real-time investigation of tumour dynamics.
Authors: D. Pierangeli, V. Palmieri, G. Marcucci, C. Moriconi, G. Perini, M. De Spirito, M. Papi, C. Conti
Our paper on the applications of machine learning to the design of topological photonic device was recently published by Communications in Physics, a new open access journal of the Nature group.
Topological concepts open many new horizons for photonic devices, from integrated optics to lasers. The complexity of large scale topological devices asks for an effective solution of the inverse problem: how best to engineer the topology for a specific application? We introduce a novel machine learning approach to the topological inverse problem. We train a neural network system with the band structure of the Aubry-Andre-Harper model and then adopt the network for solving the inverse problem. Our application is able to identify the parameters of a complex topological insulator in order to obtain protected edge states at target frequencies. One challenging aspect is handling the multivalued branches of the direct problem and discarding unphysical solutions. We overcome this problem by adopting a self-consistent method to only select physically relevant solutions. We demonstrate our technique in a realistic topological laser design and by resorting to the widely available open-source TensorFlow library. Our results are general and scalable to thousands of topological components. This new inverse design technique based on machine learning potentially extends the applications of topological photonics, for example, to frequency combs, quantum sources, neuromorphic computing and metrology.
Pilozzi, Farrelly, Marcucci, Conti in ArXiv:1803.02875