In a recent paper, we demonstrated an optical deep neural network with a real living piece of brain tumor (a 3D “tumour model”). We think this is the first example of a hybrid living/photonic hardware: a sort of artificially intelligent device performing optical functions and detecting tumour morphodynamics (including the effect of chemotherapy)
Deep optical neural network by living tumour brain cells
Abstract: The new era of artificial intelligence demands large-scale ultrafast hardware for machine learning. Optical artificial neural networks process classical and quantum information at the speed of light,
and are compatible with silicon technology, but lack scalability and need expensive manufacturing of many computational layers. New paradigms, as reservoir computing and the extreme learning machine, suggest that disordered and biological materials may realize artificial neural networks with thousands of computational nodes trained only at the input and at the readout. Here we employ biological complex systems, i.e., living three-dimensional tumour brain models, and demonstrate a random neural network (RNN) trained to detect tumour morphodynamics via
image transmission. The RNN, with the tumour spheroid 19 as a three-dimensional deep computational reservoir, performs programmed optical functions and detects cancer morphodynamics from laser-induced hyperthermia inaccessible by optical imaging. Moreover, the RNN quantifies the effect of chemotherapy inhibiting tumour growth. We realize a non-invasive smart probe for cytotoxicity assay, which is at least one order of magnitude more sensitive with respect to conventional imaging. Our random and hybrid photonic/living system is a novel artificial machine for computing and for the real-time investigation of tumour dynamics.
Authors: D. Pierangeli, V. Palmieri, G. Marcucci, C. Moriconi, G. Perini, M. De Spirito, M. Papi, C. Conti
One of the most controversial phenomena in nonlinear dynamics is the reappearance of initial conditions. Celebrated as the Fermi-Pasta-Ulam-Tsingou problem, the attempt to understand how these recurrences form during the complex evolution that leads to equilibrium has deeply influenced the entire development of nonlinear science. The enigma is rendered even more intriguing by the fact that integrable models predict recurrence as exact solutions, but the difficulties involved in upholding integrability for a sufficiently long dynamic has not allowed a quantitative experimental validation. In natural processes, coupling with the environment rapidly leads to thermalization, and finding nonlinear multimodal systems presenting multiple returns is a long-standing open challenge. Here, we report the observation of more than three Fermi-Pasta-Ulam-Tsingou recurrences for nonlinear optical spatial waves and demonstrate the control of the recurrent behavior through the phase and amplitude of the initial field. The recurrence period and phase shift are found to be in remarkable agreement with the exact recurrent solution of the nonlinear Schrödinger equation, while the recurrent behavior disappears as integrability is lost. These results identify the origin of the recurrence in the integrability of the underlying dynamics and allow us to achieve one of the basic aspirations of nonlinear dynamics: the reconstruction, after several return cycles, of the exact initial condition of the system, ultimately proving that the complex evolution can be accurately predicted in experimental conditions.
D. Pierangeli, M. Flammini, L. Zhang, G. Marcucci, A. J. Agranat,
P. G. Grinevich, P. M. Santini, C. Conti, and E. DelRe in PHYSICAL REVIEW X 8, 041017 (2018)
A landmark of statistical mechanics, spin-glass theory describes critical phenomena in disordered systems that range from condensed matter to biophysics and social dynamics. The most fascinating concept is the breaking of replica symmetry: identical copies of the randomly interacting system that manifest completely different dynamics. Replica symmetry breaking has been predicted in nonlinear wave propagation, including Bose-Einstein condensates and optics, but it has never been observed. Here, we report the experimental evidence of replica symmetry breaking in optical wave propagation, a phenomenon that emerges from the interplay of disorder and nonlinearity. When mode interaction dominates light dynamics in a disordered optical waveguide, different experimental realizations are found to have an anomalous overlap intensity distribution that signals a transition to an optical glassy phase. The findings demonstrate that nonlinear propagation can manifest features typical of spin-glasses and provide a novel platform for testing so-far unexplored fundamental physical theories for complex systems.
Davide Pierangeli, Andrea Tavani, Fabrizio Di Mei, Aharon J. Agranat, Claudio Conti, Eugenio Del Re, Nature Communications 8:1501 (2017)
Biometic random lasers
Living organisms have evolved well-adapted structures and
materials over geological eras. Through evolutional selection,
nature has devised effective solutions to all sorts of complicated
real-world problems and, following Leonardo Da Vinci,
humans have looked at nature to reach answers. The young
field of biomimetics has given rise to new technologies inspired
by nature’s strategy for materials and devices optimized from
the macroscale to the nanoscale.
Neda Ghofraniha, Luca La Volpe, Daniel Van Opdenbosch, Cordt Zollfrank, and Claudio Conti realize a novel random laser device made by biotemplated paper, and demonstrate the control of mode size and interaction. The work was published in Advanced Optical Materials.
Shock generation is a leading topic in nonlinear physics and optics. Shock waves occur whenever one enters highly nonlinear regimes either in time or in space. The origin of the undular bores is among the mysterious dynamics of shock wave generation. The undular bores are the fast oscillations that regularize the wave-breaking after the shock; their features are very difficult to understand theoretically.
A typical phenomenon is the appearance of the Batman ears in the optical intensity when the shock occurs; these “ears” are very pronounced peaks limiting the region of the shock and including undulars bores. Figures above show the Batman ears in the far field of a shock wave genereated in the spatial nonlinear optical propagation. Beyond numerical simulations, we do not have a complete theoretical description of this effect.
In a paper published in Optics Express (arXiv:1601.05796)Maria Chiara Braidotti, Silvia Gentilini, and Claudio Conti show that Gamow vectors of the reversed harmonic oscillator provide a new theoretical tool for the quantitative description of spatial shock waves in nonlocal media. The analytical calculations perfectly reproduce our experiments. This opens a number of possibilities for describing and controlling the shock waves in highly nonlocal and non-instantaneous media. The results also show the validity of the novel theoretical methods inherited by the so-called “time-asymmetric quantum-mechanics.”
The picture above shows the comparison between experiments and the analytically calculated Gamow vectors.