Tsunami of light launched against 3D-printed tumor cells

Nature Communications 14, 4662 (2023)

Extreme waves are intense and unexpected wavepackets ubiquitous in complex systems. In optics, these rogue waves are promising as robust and noise-resistant beams for probing and manipulating the underlying material. Localizing large optical power is crucial especially in biomedical systems, where, however, extremely intense beams have not yet been observed. We here discover that tumor-cell spheroids manifest optical rogue waves when illuminated by randomly modulated laser beams. The intensity of light transmitted through bio-printed three-dimensional tumor models follows a signature Weibull statistical distribution, where extreme events correspond to spatially-localized optical modes propagating within the cell network. Experiments varying the input beam power and size indicate that the rogue waves have a nonlinear origin. We show that these nonlinear optical filaments form high-transmission channels with enhanced transmission. They deliver large optical power through the tumor spheroid, and can be exploited to achieve a local temperature increase controlled by the input wave shape. Our findings shed light on optical propagation in biological aggregates and demonstrate how nonlinear extreme event formation allows light concentration in deep tissues, paving the way to using rogue waves in biomedical applications, such as light-activated therapies.

Variational quantum algorithm for Gaussian discrete solitons and their boson sampling

In the context of quantum information, highly nonlinear regimes, such as those supporting solitons, are marginally investigated. We miss general methods for quantum solitons, although they can act as entanglement generators or as self-organized quantum processors. We develop a computational approach that uses a neural network as a variational ansatz for quantum solitons in an array of waveguides. By training the resulting phase-space quantum machine learning model, we find different soliton solutions varying the number of particles and interaction strength. We consider Gaussian states that enable measuring the degree of entanglement and sampling the probability distribution of many-particle events. We also determine the probability of generating particle pairs and unveil that soliton bound states emit correlated pairs. These results may have a role in boson sampling with nonlinear systems and in quantum processors for entangled nonlinear waves

https://arxiv.org/abs/2110.12379

https://link.aps.org/doi/10.1103/PhysRevA.106.013518

The Artificial Intelligence of Waves

In a paper published in Physical Review Letters, with title

Theory of Neuromorphic Computing by Waves: Machine Learning by Rogue Waves, Dispersive Shocks and Solitons

we study artificial neural networks with nonlinear waves as a computing reservoir. We discuss universality and the conditions to learn a dataset in terms of output channels and nonlinearity. A feed-forward three-layered model, with an encoding input layer, a wave layer, and a decoding readout, behaves as a conventional neural network in approximating mathematical functions, real-world datasets, and universal Boolean gates.
The rank of the transmission matrix has a fundamental role in assessing the learning abilities of the wave.
For a given set of training points, a threshold nonlinearity for universal interpolation exists. When considering the nonlinear Schrödinger equation, the use of highly nonlinear regimes implies that solitons, rogue, and shock waves do have a leading role in training and computing. Our results may enable the realization of novel machine learning devices by using diverse physical systems, as nonlinear optics, hydrodynamics, polaritonics, and Bose-Einstein condensates. The application of these concepts to photonics opens the way to
a large class of accelerators and new computational paradigms. In complex wave systems, as multimodal fibers, integrated optical circuits, random, topological devices, and metasurfaces, nonlinear waves can be employed to perform computation and solve complex combinatorial optimization.

The paper was selected as Editors’Suggestion and Featured in Physics

See also

https://arxiv.org/abs/1912.07044

Solitonization of the Anderson localization and rogue waves

In a paper published in Optics Express, M. Saleh, C. Conti, and F. Biancalana, report on a new scenario during rogue wave generation. The random intensity profile of an optical pulse fosters Anderson localization of waves that triggers the generation of solitons (the so-called solitonization) and ultimately rogue events. The process also involves event horizons in analogy with black holes. This is a further evidence of the complexity of supercontinuum generation and extreme events in nonlinear fibre optics.