Rachel Won in The power of light-driven computing highlights the plenary talk in CLEO/EUROPE-EQEC 2023 about photonic computing machines in Nature Photonics.
Nature Photonics on the Plenary at CLEO/EUROPE-EQEC 2023
Category: Our experiments
Tsunami of light launched against 3D-printed tumor cells
Nature Communications 14, 4662 (2023)
Extreme waves are intense and unexpected wavepackets ubiquitous in complex systems. In optics, these rogue waves are promising as robust and noise-resistant beams for probing and manipulating the underlying material. Localizing large optical power is crucial especially in biomedical systems, where, however, extremely intense beams have not yet been observed. We here discover that tumor-cell spheroids manifest optical rogue waves when illuminated by randomly modulated laser beams. The intensity of light transmitted through bio-printed three-dimensional tumor models follows a signature Weibull statistical distribution, where extreme events correspond to spatially-localized optical modes propagating within the cell network. Experiments varying the input beam power and size indicate that the rogue waves have a nonlinear origin. We show that these nonlinear optical filaments form high-transmission channels with enhanced transmission. They deliver large optical power through the tumor spheroid, and can be exploited to achieve a local temperature increase controlled by the input wave shape. Our findings shed light on optical propagation in biological aggregates and demonstrate how nonlinear extreme event formation allows light concentration in deep tissues, paving the way to using rogue waves in biomedical applications, such as light-activated therapies.
Plenary Speaker at CLEO/Europe-EQEC 2023
Biosensing with free space whispering gallery mode microlasers
Highly accurate biosensors for few or single molecule detection play a central role in numerous key fields, such as healthcare and environmental monitoring. In the last decade, laser biosensors have been investigated as proofs of concept, and several technologies have been proposed. We here propose a demonstration of polymeric whispering gallery microlasers as biosensors for detecting small amounts of proteins down to 400 pg. They have the advantage of working in free space without any need for waveguiding for input excitation or output signal detection. The photonic microsensors can be easily patterned on microscope slides and operate in air and solution. We estimate the limit of detection up to 148 nm/RIU for three different protein dispersions. In addition, the sensing ability of passive spherical resonators in the presence of dielectric nanoparticles that mimic proteins is described by massive ab initio numerical simulations.
Observation of terahertz transition from Fano resonances to bound states in the continuum
Bound states in the continuum (BIC) in metamaterials have recently attracted attention for their promising applications in photonics. Here, we investigate the transition from Fano resonances to BIC, at terahertz (THz) frequencies, of a one-dimensional photonic crystal slab made of rectangular dielectric rods. Simulations performed by an analytical exact solution of the Maxwell equations showed that symmetry-protected, high-quality factor (Q), BIC emerge at normal incidence. For non-normal incidence, BIC couple with the freely propagating waves and appear in the scattering field as a Fano resonance. Simulations were verified by realizing the photonic crystal slab by 3D-printing technique. THz time-domain spectroscopy measurements as a function of the incidence angle matched the simulation to good accuracy and confirmed the evolution of Fano resonances to high-Q resonances typical of BIC. These results point out the design of highly sensitive and low-cost THz devices for sensing for a wide range of applications.